HSP90B1 promoted glioma radioresistance and migratory and invasive capabilities by regulating RhoC expression (IMAGE)
Caption
: (A, B) LN229 (A) or U87 (B) cell was divided into four groups: control, HSP90B1 knockdown, RhoC overexpression control, and HSP90B1 knockdown combined with RhoC overexpression. Two days after radiotherapy, apoptosis marker expression was analyzed via Western blot. (C, D) Flow cytometry was used to assess the impact of HSP90B1 knockdown and combined knockdown of HSP90B1 with overexpression of RhoC on cell apoptosis following radiotherapy. (E–H) Through Transwell assays, the effects of HSP90B1 knockdown and combined knockdown of HSP90B1 with overexpression of RhoC on the migratory and invasive capabilities of LN229 (E, F) and U87 (G, H) cells were evaluated.
Credit
Jiacheng Xu, Yuduo Guo, Jingjing Yang, Guanjie Shang, Weihai Ning, Deshan Liu, Hongwei Zhang, Yongmei Song
Usage Restrictions
Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND