Disruption of zinc homeostasis impairs the redox homeostasis in the ER (IMAGE)

Kyushu University

Disruption of zinc homeostasis impairs the redox homeostasis in the ER

Caption

Inhibition of ZIP7, which localizes to the ER membrane, leads to the accumulation of Zn2+ within the ER. This excess Zn2+ directly inhibits the activity of Ero1α, thereby impairing the reoxidation of PDI. As a result, disulfide bond formation in newly synthesized secretory proteins is prevented, leading to the accumulation of misfolded proteins and the induction of ER stress.

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Kenji Inaba / Kyushu University

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