Redox pathway underlying the formation of native conformations of secretory proteins in the endoplasmic reticulum (ER) (IMAGE)

Kyushu University

Redox pathway underlying the formation of native conformations of secretory proteins in the endoplasmic reticulum (ER)

Caption

Newly synthesized secretory proteins are translocated into the ER, where disulfide bonds are formed between appropriate pairs of cysteine residues, enabling acquisition of their native conformations. Ero1α and PDI are central enzymes that catalyze this series of oxidation-reduction (redox) reactions.

Credit

Kenji Inaba / Kyushu University

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