Figure 1. Schematic illustration of astrocyte-derived Type I collagen production and neuronal cell death in ischemic stroke (IMAGE)

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Figure 1. Schematic illustration of astrocyte-derived Type I collagen production and neuronal cell death in ischemic stroke

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Following ischemic injury, excessive hydrogen peroxide (H₂O₂) is generated, leading to astrocyte activation. Activated astrocytes produce collagen proteins, which contribute to the formation of a glial barrier and induce neuronal cell death. Importantly, inhibition of collagen production or early elimination of excessive hydrogen peroxide prevents the progression of neuronal damage and restores motor function, as demonstrated in non-human primate models.

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Institute for Basic Science

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