Figure 2. Schematic illustration of astrocyte-derived Type I collagen production and neuronal cell death in ischemic stroke (IMAGE)

Institute for Basic Science

Figure 2. Schematic illustration of astrocyte-derived Type I collagen production and neuronal cell death in ischemic stroke

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In an ischemic stroke model, excessive hydrogen peroxide (H₂O₂) generated at the early stage activates astrocytes, leading to the production of Type I collagen through gene expression within the cells. The collagen is subsequently secreted into the extracellular space, where it activates microglia, promotes glial barrier formation, and induces neuronal cell death by binding to integrin receptors on neurons.

Importantly, suppression of Type I collagen production using viral approaches or early elimination of excessive hydrogen peroxide can prevent the progression of stroke pathology.

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Institute for Basic Science

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