Fig 2 (IMAGE)

Nano Life Science Institute (NanoLSI), Kanazawa University

Fig 2

Caption

Fig 2: Ligand-dependent Wnt signaling drives liver metastasis in gastric cancer. Wnt ligand-expressing gastric cancer cells activate Wnt signaling in both tumor cells and surrounding stromal fibroblasts. In the liver metastatic niche, Wnt signaling cooperates with TGF-β signaling to activate cancer-associated fibroblasts (CAFs), inducing hyaluronan production. This hyaluronan-rich stroma supports the establishment and growth of metastatic tumors.

Credit

© 2026 Furutani Research Group, Kanazawa University.

Usage Restrictions

The image may only be used with appropriate caption and credit.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.