The schematic diagram illustrating that nuclear and cytoplasmic coordinately regulate breast cancer progression. (IMAGE)
Caption
In the cytoplasm, USP30-AS1 interacts with HnRNPF to prevent the binding between HnRNPF and p21 mRNA, resulting in the destabilization of p21 mRNA. In the nucleus, USP30-AS1 binds to EZH2 and suppresses the enrichment of EZH2 on the c-Myc promoter, leading to the epigenetic up-regulation of c-Myc.
Credit
Yapei Jiang, Weijie Liao, Qilei Xin, Ruonan Wang, Guanglan Lin, Jia Li, Zijian Yang, Shiyue Yang, Haowei Zhang, Xiaolin Li, Qian Peng, Yaou Zhang, Weidong Xie, Naihan Xu
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CC BY-NC-ND