AAVT42-BDNF treatment mainly regulated pathways mediating neuronal structure organization and synaptic transmission in 3 × Tg mice (IMAGE)
Caption
(A) The volcano plot illustrating differentially expressed genes (DEGs) in the AAVT42-BDNF treatment and AAVT42-GFP hippocampus. Dotted lines highlighting the P-value = 0.05 (y-axis) and fold change = 2 (x-axis), blue dots showed genes expressed at higher levels in AAVT42-GFP hippocampus, and red dots showed genes expressed at higher levels in AAVT42-BDNF hippocampus.
(B) The expression heat map of TOP 30 up-regulated genes and down-regulated genes of AAVT42-BDNF vs. AAVT42-GFP.
(C) STRING protein–protein interaction work. Network of top 30 up-regulated proteins in the hippocampus after AAVT42-BDNF administration. Different colors reflected different kinds of connection evidence between proteins.
(D) Gene ontology enrichment analysis of the up-regulated DEGs for biological process.
(E) The expression heat map of DEGs enriched in the modulation of synaptic transmission and dendrite morphogenesis.
(F) STRING protein–protein interaction work. Network of top 30 down-regulated proteins in the hippocampus after AAVT42-BDNF administration. Different colors reflected different kinds of connection evidence between proteins.
(G) Gene ontology enrichment analysis of the down-regulated DEGs for biological process.
(H) The expression heat map of DEGs enriched in the Aging and Regulation of BMP signaling.
Credit
Siqi Tang, Wenshu Luo, Shihao Wu, Meng Yuan, Jiashuo Wen, Guoshen Zhong, Leshan Shen, Wei Jiang, Cheng Cheng, Xia Wu, Xiao Xiao
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