Schematic diagram illustrating OXCT11 in colorectal cancer (IMAGE)
Caption
In colorectal cancer, OXCT1 is a suppressor of tumor progression, and low expression of OXCT1 is associated with poor prognosis. The transcriptional level of OXCT1 is promoted by YY1, and OXCT1 inhibits the expression of CDK8 and β-catenin by suppressing H3 acetylation, thereby further inhibiting liver metastasis of colorectal cancer.
Credit
Chenhao Li, Deao Gong, Xiaoqun Shan, Kang Wu, Jiayao Yang, Rong Zhang, Ye Huang, Kai Wang, Ni Tang, Yuxi Zhu
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CC BY-NC-ND