Model of PPI and PARPi combination synergy. (IMAGE)
Caption
(A) FASN regulation of PARP1 expression and its inhibition by PPI in DNA damage repair and cancer cell survival.
(B) FASN in repair secondary double-strand DNA break (DSB) by regulating PARP1 and BRCA1 and its inhibition by PPI therein.
(C) PARP1 retention in chromatin due to inhibition of FASN by 5HLS, facilitating PARP1 trapping by PAPRi.
Credit
Sophia Josephraj, Chao J. Wang, Qingbin Cui, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang
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