The clinical significance of the ATAD2-E2F1-PDK1 axis in glioma (IMAGE)
Caption
A, B) Analysis using the GlioVis database showed a positive correlation between the expressions of ATAD2, E2F1, and PDK1, as determined by the Spearman correlation test.
(C) Representative cases showed the expression of E2F1 and PDK1 in glioma clinical specimens with low and high expression of ATAD2. Scale bar: 100 μm.
(D) Spearman's correlation analysis of ATAD2, E2F1, and PDK1 expression levels in glioma clinical specimens.
(E) Kaplan–Meier analysis and log-rank test of survival rates across distinct co-expression groups of ATAD2, E2F1, and PDK1 in the CGGA cohort. P values were adjusted for multiple group comparisons using the Bonferroni method.
(F) Graphical diagram illustrating that ATAD2 promotes glioma progression and synergizes with E2F1 to increase PDK1 expression. The figure was created using Figdraw (www.figdraw.com). Statistical significance is denoted as follows: ∗∗∗, P < 0.001.
Credit
Shenghua Zhuo, Liangwang Yang, Zhimin Chen, Shenbo Chen, Shuo Yang, Taixue Chen, Wen-Shu Wu, Kai Wang, Kun Yang
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