The effect of cell membrane topology on tumor invasion. (IMAGE)
Caption
Epithelial cell carcinogenesis and abnormal proliferation induce cell crowding by physical compression, causing tumor cell deformation and changes in surface topology. The increased membrane curvature and the decreased membrane tension between the apical and basal sides drive cancerous epithelial cells to transform into invading amoebic or mesenchymal cells.
Credit
Chenhe Liu, Shijiang Wang, Xin Zhang, Yifan Han, Min Tan, Jiehou Fan, Jing Du, Yubo Fan, Xinbin Zhao
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Credit must be given to the creator. Only noncommercial uses of the work are permitted. No derivatives or adaptations of the work are permitted.
License
CC BY-NC-ND