Molecular mechanism of DNA targeting and cleavage by LINE-1 reverse transcriptase (IMAGE)

Chinese Academy of Sciences Headquarters

Molecular mechanism of DNA targeting and cleavage by LINE-1 reverse transcriptase

Caption

(A) LINE-1 specifically recognizes fork-like DNA structures formed during replication and achieves double-stranded DNA cleavage through conformational changes in the EN domain. (B) Structural comparison of reverse transcriptases from lower to higher organisms

Credit

XU Ruiming's group

Usage Restrictions

News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.