Effects of administration of the DRD3 agonist cariprazine on the level of autophagy induced by circFKBP8(5S,6) or its encoded protein cFKBP8 in mice. (IMAGE)
Caption
(A–D) Representative western blots (A) and quantitative analysis (B–D) of LC3B, p62, and beclin 1 after intervention with the DRD3 agonist cariprazine. n = 6. (E, F) Representative immunofluorescence staining images (E) and quantitative evaluations (F) of LC3B puncta (LC3B-labeling, red) in PrL neurons (EGFP-labeling, green) after intervention with the DRD3 agonist cariprazine. n = 4. Scale bar = 20 μm. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. Data were represented as mean ± standard error of the mean. DRD3, dopamine D3 receptor; LC3B, microtubule-associated protein 1 light chain 3B; EGFP, enhanced green fluorescent protein.
Credit
Dandan Xu, Zihan Huang, Gaojia Zhang, Jiao Jiao, Yujia Cao, Mengyu Liu, Yan Kong, Zhijun Zhang
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