(IMAGE)

Innovation Center of NanoMedicine

Caption

Our study progresses from the rational design of polyplex micelles to the mechanistic elucidation of mRNA degradation, revealing RNase infiltration—rather than carrier dissociation—as the principal cause of mRNA fragmentation. In vivo FRET imaging confirms the structural robustness of polyplex micelles during blood circulation. However, qPCR-based analysis of mRNA integrity under identical conditions reveals degradation of the encapsulated mRNA. These findings suggest that future polyplex designs must incorporate protective features that block RNase access to the mRNA-containing core.

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Reproduced from J. Control. Release 384, 113935 (2025)　 under a Creative Commons Attribution License 4.0 (CC BY).

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