HFpEF subtype identification based on the ARDEG diagnostic model. (IMAGE)

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HFpEF subtype identification based on the ARDEG diagnostic model.

Caption

(A) The heatmap exhibiting the two HFpEF clusters with k = 2 based on the ARDEGs. (B) Cumulative distribution function (CDF) for k = 2–9. (C) Delta diagram illustrating the variations of the area under the CDF curve for k = 2–9. (D) PCA based on the results of the consensus clustering analysis. (E) ARDEG expressions in two different HFpEF clusters. (F) Volcano plot of the DEGs in two different HFpEF clusters. (G) Venn diagram of nine key DEGs identified by intersecting the DEGs and ARDEGs. (H) The heatmap exhibiting expression of the key DEGs in two different HFpEF clusters. HFpEF, heart failure with preserved ejection fraction; CDF, cumulative distribution function; PCA, principal component analysis; DEGs, differentially expressed genes; ARDEGs, ageing-related DEGs.

Credit

Genes & Diseases

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License

CC BY-NC-ND

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