(IMAGE)
Caption
bishu-1 synthesizes diacylglycerol and maintains the expression of the transcription factor broad. broad binds to the regulatory region of cool receptors IR25a and IR21a to maintain their expression. In wild-type larvae, this mechanism preserves cold avoidance behavior. Disruption of bishu-1 leads to reduced responsiveness of cooling-sensitive neurons (DOCCs) through decreased expression of broad and IRs, causing larva to remain at cool temperatures. Based on this mutant phenotype, we named the gene bishu, which is a Chinese word for “summering”.
Credit
Takaaki Sokabe
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