Figure 4. Fluorescent visualization of defective tendon maturation in Scx-deficient mice (IMAGE)

Hiroshima University

Figure 4. Fluorescent visualization of defective tendon maturation in Scx-deficient mice

Caption

Three-dimensionally reconstructed images of the developing paw and wrist of an E16.5 ScxTomato;Sox9EGFP embryo with a C57BL/6 background via two-photon excitation fluorescence (TPEF) microscopy and SHG imaging. Red and green fluorescence indicates Scx+ tendons/ligaments and Sox9+ cartilaginous bone primordia, respectively. Light blue SHG signals indicate collagen bundles in the ScxTomato;Sox9EGFP embryo. Overlay of the TPEF/SHG image.

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Reproduced with permission from Development, Yu et al., 2025.

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