Quantification of KCs and MoMFs in healthy and diseased livers. (IMAGE)

First Hospital of Jilin University

Quantification of KCs and MoMFs in healthy and diseased livers.

Caption

(A) The location information of KCs and MoMFs from figure 2B was extracted by CellProfiler based on the expression of IBA1 and CLEC4F. The data was plotted in the lower panel. (B) Quantification of the percentage of KCs and MoMFs in naïve mice and four liver disease models as indicated (n=4). (C and D) Quantification of the percentage of KCs and MoMFs in necrotic regions and undamaged regions in ConA and APAP models. APAP, acetaminophen; CLEC4F, C-Type Lectin Domain Family 4 Member F; ConA, concanavalin A; DAPI, 4',6-diamidino-2-phenylindole; HFD, high-fat diet; IBA1, ionized calcium-binding adaptor molecule 1; KCs, Kupffer cells; MASH, metabolic dysfunction-associated steatohepatitis; MoMFs, monocyte-derived macrophages.

Credit

By Dechun Feng, Yukun Guan, Yang Wang, Luca Maccioni, Bryan Mackowiak, Bin Gao.

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License

CC BY-NC

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