Structural Features and Metal Ion-Dependent Substrate Activity of Amuc_1547. (IMAGE)

Sichuan International Medical Exchange and Promotion Association

Structural Features and Metal Ion-Dependent Substrate Activity of Amuc_1547.

Caption

(a) Overall Structure of Amuc_1547. (b) Magnesium Ion Binding Pocket in Amuc_1547 (PDB ID: 8HLS): The magnesium ion binding pocket is highlighted, featuring key loop regions (residues 285-304, 209-213) displayed in hot pink. Coordinating amino acids Glu289, Glu299, and Asp300 are presented in stick model. (c) Effect of different metal ions on the activity of Amuc_1547 to substrate 4MU-Neu5Ac.

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Dr. Tao Li and Dr. Rui Bao

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