Epigenomic alterations of iridocorneal endothelial (ICE) syndrome. (IMAGE)
Caption
(A) Differentially methylated region (DMR) and hypomethylated region (HMR) frequency in ICE syndrome. The ideogram shows, for each chromosome, from left to right: DMR comparing ICE syndrome (n = 48) to normal Chinese (n = 45), and HMR frequency in 100-bp windows in the ICE samples. The volcano plots show differentially methylated loci comparing ICE syndrome to normal Chinese. (B) The top 15 recurrent HMRs among >10% of ICE patients also showed differential methylation (<−0.1) versus normal Chinese controls. (C) Gene Ontology analysis of differentially methylated genes. Seven significantly enriched terms of biological processes, cell components, and molecular functions are shown, respectively. The adjusted P-value was set to 0.05.
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Genes & Diseases
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