The team has identified numerous SORL1 genetic variants that protect against the risk of Alzheimer’s disease (AD) in the East Asian and European populations. (IMAGE)

Hong Kong University of Science and Technology

The team has identified numerous SORL1 genetic variants that protect against the risk of Alzheimer’s disease (AD) in the East Asian and European populations.

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The team has identified numerous SORL1 genetic variants that protect against the risk of Alzheimer’s disease (AD) in the East Asian and European populations. By comparing the genetic structure across different populations, the team has further dissected the most critical AD-protective SORL1 variants in both groups. The specific genetic variant Hap_A of SORL1 is associated with an alleviated cognitive decline in patients with AD, indicating its important protective mechanism.

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