the biological functions of selenomprotein families of GPXs, TXNRDs, DIOs, and Msr (IMAGE)

Science China Press

the biological functions of selenomprotein families of GPXs, TXNRDs, DIOs, and Msr

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GPXs are responsible for reducing reactive oxygen species (ROS), such as hydrogen peroxide (H2O2) to water by using glutathione (GSH). TXNRDs not only reduce thioredoxin (Trd), but also non-disulfide substrates, such as hydroperoxides, by consuming NADPH. DIOs are mainly involved in regulating deiodination reactions, which converting T4 to T3 or rT3, and ultimately to T2. MSRs can reduced methionine sulfoxide to rescue the post-translational oxidative modification on methionine residue.

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