Gastrointestinal disorders impacting goblet cell (GC) function. (IMAGE)

First Hospital of Jilin University

Gastrointestinal disorders impacting goblet cell (GC) function.

Caption

The malfunction of GCs, marked by changes in numbers, abnormal differentiation and modified mucin production, plays a substantial role in the onset and advancement of various gastrointestinal disorders. These include inflammatory bowel disease, colorectal cancer, mucinous adenocarcinoma, pathogen infections, cystic fibrosis and liver diseases. Understanding the mechanisms behind these disruptions is essential for devising targeted therapies aimed at reinstating GC function and enhancing overall gut health. Created with BioRender.com. CLCA1, calcium-activated chloride channel regulator 1; FCGBP, Fc-binding protein; GAP, GC-associated antigen passage; IL-18, interleukin 18; MUC2, mucin 2; RELM-β, resistin-like molecule β; TFF3, trefoil factor 3; ZG16, Zymogen granule protein 16.

Credit

By Fernanda Raya Tonetti, Alvaro Eguileor, Cristina Llorente.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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