The pancreatic lysosomal function in health and disease. (IMAGE)

First Hospital of Jilin University

The pancreatic lysosomal function in health and disease.

Caption

The lysosome plays a critical role in maintaining cellular proteostasis, organelle function, ion balance, immunity as well as metabolic sensing and homeostasis in the pancreas. Disruption of the lysosomal stress response contributes to immuno-metabolic imbalance in diabetes mellitus. CFRD, cystic fibrosis-related diabetes; GDM, gestational diabetes mellitus; T1D, type 1 diabetes; T2D, type 2 diabetes.

Credit

By Meihua Hao, Sara C Sebag, Qingwen Qian, Ling Yang.

Usage Restrictions

Credit must be given to the creator. Only noncommercial uses of the work are permitted.

License

CC BY-NC

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