Mechanism of Neurodegeneration Involving G4 Assembly (IMAGE)

Kumamoto University

Mechanism of Neurodegeneration Involving G4 Assembly

Caption

The trigger for neurodegeneration is the assembly of G4 structures driven by increased intracellular calcium ions (Ca2+) due to cellular stress. α-Synuclein binds directly to G4, shifting into an aggregate-prone structure that employs G4 as a scaffold to form harmful clusters. Therefore, inhibiting G4 assembly can prevent α-synuclein aggregation, helping to protect against neuronal function loss.

Credit

Norifumi Shioda, Yasushi Yabuki, Kumamoto University

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