Tracking Genomes for Diseases (IMAGE) Institute of Science and Technology Austria Caption Traditional GWAS “black box”-like models use statistics to predict disease risk from genomes. Most diseases are polygenic, meaning many sites in the genome contribute towards disease risk, making it hard to pinpoint the underlying biological mechanisms. Credit Natália Ružičková/ISTA Usage Restrictions - License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.