Fig. 2 (IMAGE)

Immunology Frontier Research Center (IFReC) - Osaka University

Fig. 2

Caption

A. A 3D co-culture model of human intestinal cDC1s and monolayered intestinal epithelial cells derived from enteroids. Pyruvate led to transepithelial dendrite formation of cDC1s. Red, cDC1s; blue, nuclei. Scale bar, 10 μm. B. GPR31+ cDC1s took up Escherichia coli (E. coli) from the epithelial side under pyruvate stimulation. Green, cDC1s and epithelial cells; Red, E. coli; blue, nuclei. Scale bar, 10 μm.

Credit

2024, Eri Oguro-Igashira, Pyruvate–GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells, Proceedings of the National Academy of Sciences of the United States of America

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