The Role of PGD2-DP and PGE2-EP4 Pathways in Implantation and Decidualization. (IMAGE)

Kumamoto University

The Role of PGD2-DP and PGE2-EP4 Pathways in Implantation and Decidualization.

Caption

In the early stage of implantation (Day 4.5), DP, EP2, and EP4 receptors are expressed in the luminal epithelium (LE), contributing to epithelial breakdown through the actions of PGD2 and PGE2, produced by COX-2. By the later stage (Day 5.5), DP and EP4 receptors are found in the mesometrial and anti-mesometrial stroma, respectively, promoting decidualization in cooperation with PGD2 and PGE2.

Credit

Yukihiko Sugimoto, Tomoaki Inazumi, Kumamoto University

Usage Restrictions

Only to be used in content reporting on this research. Credit must be given to the creator.

License

Original content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.