Comparison of DNA Replication Mechanism in ES and non-ES cells (IMAGE)

National Institutes of Natural Sciences

Comparison of DNA Replication Mechanism in ES and non-ES cells

Caption

Mouse ES cells present active origin firing and replication forks that progress slowly throughout S phase. These features are integral aspects of genome replication ensuring genome integrity in ES cells. On the other hand, non-ES cells initially present slow forks with frequent fork pausing, which then accelerate and reduce fork pausing as S phase proceeds.

Credit

T. Tsubouchi

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