Innovative technology enhances cellular and molecular insights into kidney lesions
Peer-Reviewed Publication
Updates every hour. Last Updated: 15-Jul-2025 14:11 ET (15-Jul-2025 18:11 GMT/UTC)
Researchers have demonstrated the feasibility of a morphological-based approach to interpreting spatial transcriptomic (ST) data, helping to improve understanding of the lesions that occur in chronic kidney disease (CKD), at both the cellular and molecular levels. A recent study in The American Journal of Pathology, published by Elsevier, details how this new method could lead to the identification of new biomarkers and therapeutic strategies for patients.
Scientists at Gladstone Institutes have developed a drug that mimics the effects of breathing low oxygen. In mice with Leigh Syndrome—the most common childhood mitochondrial disease—the HypoxyStat drug extended lifespan by more than 3-fold and reversed brain damage and muscle weakness, even when given during late stages of disease.
Despite similar availability of diagnostic technologies to women of different racial and ethnic groups, significant disparities were seen in who actually received same-day diagnostic services and biopsies after abnormal mammogram findings, new research shows. Even when breast-care facilities had the necessary technology and capabilities, minority groups were less likely than white women to receive diagnostic imaging on the same day as an abnormal screening result. Black women in particular were less likely to receive same-day biopsies, compared with white women.
The findings of a retrospective study are to be published Feb. 18 in the journal Radiology. The lead author is Dr. Marissa Lawson, assistant professor of radiology at the University of Washington School of Medicine. Dr. Christoph Lee, UW professor of radiology, was senior author.
“We’re looking at how the diagnostic workup process might contribute to the population disparities we see with breast-cancer outcomes,” Lawson said. “It was surprising to find similar availability (of technologies) across racial and ethnic groups. But we still saw big differences in who was getting those same-day services.”