Left-right symmetry-breaking of a cellular flow occurs earlier than node formation
Peer-Reviewed Publication
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Most animals exhibit external left-right (LR)-symmetric appearance and -asymmetric internal organs. A fundamental question in development is when and how the LR-asymmetry is established for the internal organs, keeping the external body plan bilaterally symmetric. Researchers from Kumamoto Univ., Univ. of Miami, and UCSF examined the initiation of LR symmetry breaking during embryonic development, by using chick embryos as a model system.
Researchers at The Jackson Laboratory and UConn Health discovered that cancer cells suppress "poison exons" — genetic elements that act as an off switch for protein production — in a key gene called TRA2β, promoting tumor growth. By using antisense oligonucleotides (ASOs) to restore poison exon activity, the team effectively reactivated this kill switch, offering a potential new precision therapy for aggressive, hard-to-treat cancers.