Cardiovascular and metabolic diseases are primary drivers of excess US deaths compared to other high-income countries
Peer-Reviewed Publication
Updates every hour. Last Updated: 8-May-2026 14:16 ET (8-May-2026 18:16 GMT/UTC)
A new study in JAMA Network Open found that between 1999-2022, the annual number of excess US deaths—deaths that would not have occurred had the mortality rate in the US been the same as in other HICs—increased steadily through 2019 and then rose rapidly during the COVID-19 pandemic. By 2022, all-cause mortality rates in the US were 38 percent higher than in other HICs. An estimated 12.7 million US deaths could have been averted during this period if US mortality rates mirrored those of its peers. The authors refer to these excess US deaths as “missing Americans.”
A new study explored whether women visualised a vaccine would have a positive or negative impact on their babies, and if that affected their decision to be vaccinated. The findings, published in the journal Social Science & Medicine, showed that mental images were common and – depending on whether that mental image was a positive or negative one, and about the impacts of diseases or the vaccine itself – could be used in some cases to predict if and when the women ultimately became vaccinated during pregnancy.
Scientists at La Jolla Institute for Immunology (LJI) have discovered that the influenza vaccine FluMist can stimulate immunity in the upper airways of adults. This is the first time researchers have tracked how immune cells in the upper airways respond to an intranasal vaccine (given via a spray in the nose). The new study gives scientists a guide for measuring the effectiveness of new intranasal vaccines against RSV, COVID-19, and other respiratory diseases.
An international team led by Dr. Adolfo Poma (IPPT PAN, Poland) shows that antibody effectiveness depends not only on binding strength but also on their stability under mechanical forces. The findings provide a new framework for designing more robust antiviral therapeutics.
New research using data from the Canadian Longitudinal Study on Aging (CLSA) reveals that employment stability and in-person work buffered older adults against depression during the first year of COVID-19.