Recently, Pingping Zhu, Zhenzhen Chen, Qiankun He from Zhengzhou University and Xinrui Lv from Henan University published a review paper on MedComm-Oncology, which is titled "Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors". They comprehensively reviewed the recent progress in understanding and targeting of CSCs and their niche.

For the first time, researchers have revealed the high-affinity interaction between mitochondrial proteins HAX1 (intrinsically disordered) and CLPB (α-helical), uncovering their structural and functional synergy. Using NMR, the study shows HAX1's disordered region binds CLPB's helical domain with low micromolar affinity, providing mechanistic insights into diseases like cancer and mitochondrial encephalomyopathy. These findings open new avenues for targeted therapies against mitochondrial dysfunction-related disorders.

This work developed a new deep learning framework, MULGONET, to predict cancer recurrence and identify key biomarkers by integrating multi omics data (such as mRNA, DNA methylation, copy number variation). By utilizing the gene ontology (go) hierarchy, the model overcomes the challenges of data dimensionality and interpretability, and achieves higher accuracy in bladder cancer, pancreatic cancer, and gastric cancer datasets. This innovation enables clinicians to pinpoint key genes and biological pathways associated with cancer recurrence, paving the way for personalized treatment strategies.

Those who suffer myasthenia gravis experience muscle weakness that can affect the muscles we use to blink, smile and move our bodies. Researchers at UC San Diego’s School of Biological Sciences used a cutting-edge imaging technique to uncover new details about the mechanisms underlying the disease.

Researchers have discovered a way to get anti-inflammatory medicine across the blood-brain barrier, opening the door to potential new therapies for a range of conditions, including Alzheimer’s disease, multiple sclerosis, Parkinson’s disease and cancer cachexia.