City of Hope®, a leading cancer research and treatment organization, and Cellares, the first Integrated Development and Manufacturing Organization (IDMO), announce a collaboration focused on the City of Hope-developed IL13RA2-EGFR CAR T cell program addressing glioblastoma multiforme. City of Hope licensed this technology to Mustang Bio Inc. Under the collaboration, City of Hope will evaluate Cellares’ Cell Shuttle™ automated manufacturing platform and Cell Q™ automated quality control system to enable reliable, high-throughput manufacturing and quality control of its CARpool program. By engaging at the preclinical stage, the collaboration will establish platform processes and analytics purpose-built for solid tumor CAR T programs, accelerating advancement into clinical trials while enabling scalable manufacturing to meet global patient demand.

The partnership enables Fox Chase to become the first NCI-designated Comprehensive Cancer Center to implement clinical testing utilizing Arima's 3D-genomics technology in multiple tumor types as part of a standard protocol.

The Krainer lab discovered a three-oncogene circuit that helps drive the aggressive progression of pancreatic ductal adenocarcinoma. Using antisense oligonucleotide technology, the team developed a potential RNA therapy. In lab tests, the new treatment broke the cancerous circuit, reduced tumor viability, and triggered a type of programmed cell death.

Researchers at the University of Southampton have developed a promising new way to bolster the body’s immune system response to cancer.

In a study published in Nature Communications, researchers used specially engineered multi-pronged antibodies to better activate cancer-killing T cells.

The antibodies work by ‘grabbing’ and ‘clustering’ multiple immune cell receptors – boosting the signal which tells the T cell to attack the cancer.

Scientists at the University of Connecticut have developed a handheld ‘pocket microscope’ that directly visualizes DNA and proteins in living cells without stains or labels. The system uses deep-ultraviolet light to map molecules with femtogram sensitivity, achieving 308-nanometer resolution across centimeter-wide areas. The device enables instant pathology diagnosis, identifies cancer cells, and maps brain neurons -- all while preserving samples’ natural state. This technology could transform medical diagnostics, from operating rooms to space missions.