In 2008, Denmark started to offer free vaccination against human papillomavirus (HPV) with the 4-valent HPV vaccine to teenage girls around the age of 14. New data from a cohort study presenting results from the national cervical screening programme among young women who were vaccinated as girls, show that infection with HPV types covered by the vaccine has been almost eliminated.

New research in JNCCN finds that for people diagnosed with nonmetastatic low-risk prostate cancer later in life, and treated according to NCCN Guidelines, 90% were likely to survive their cancer for their remaining life-expectancy.

Metastasis researcher Dr. Joan Massagué shares four emerging insights into how cancer spreads.

In a follow-up analysis to the pivotal TOPAZ-1 study, which established the combination therapy of durvalumab (an immunotherapy drug) plus gemcitabine and cisplatin (GemCis, chemotherapy drugs) as the first-line treatment for people with advanced biliary tract cancer (aBTC), researchers have shown that after three years more than twice as many study participants treated with durvalumab plus GemCis had survived compared to those treated with a placebo plus GemCis. The new results in the Journal of Hepatology, published by Elsevier, establish a new survival benchmark for people living with aBTC and reinforce durvalumab plus GemCis as a standard of care for first-line treatment for aBTC.

CZI announced its latest AI model, GREmLN, aimed at helping researchers better understand how cells behave by focusing on the key networks that control cell behavior.

 Researchers from The University of Osaka have identified key genetic mutations linked to extracranial arteriovenous malformations (AVMs), a rare and potentially serious vascular disorder. They have revealed that these mutations activate the RAS/RAF/MEK signaling pathway and that the MAP4K4 gene may drive pathological angiogenesis. This may mean that existing cancer drugs that target the same pathway could be effective for AVM treatment, potentially paving the way for novel therapies.

Recent advances in spatial omics and single-cell omics have significantly reshaped biomarker discovery in tumor immunotherapy by addressing critical challenges posed such as tumor heterogeneity, immune evasion, and variability within the tumor microenvironment (TME).

While immunotherapeutic strategies—such as immune checkpoint inhibitors and adoptive T-cell transfer—have demonstrated promising clinical outcomes, their effectiveness is hindered by low response rates and immune-related adverse events (irAEs). Thus, identifying reliable biomarkers is essential for predicting treatment efficacy, minimizing irAEs, and facilitating patient stratification. Spatial omics integrates molecular profiling with spatial localization, providing comprehensive insights into the cellular organization and functional states of the TME. By revealing spatial patterns of immune cell infiltration and tumor heterogeneity, this approach enhances our predictive capacity for therapeutic response. Similarly, single-cell omics yields high-resolution analysis of cellular heterogeneity, capturing transcriptomic, epigenomic, and metabolic signatures at the single-cell level. The combined application of spatial and single-cell omics has led to the identification of previously undetected biomarkers, including rare immune cell subsets implicated in resistance mechanisms. Beyond spatial transcriptomics (ST), this technological landscape also includes spatial proteomics and metabolomics, which further facilitate the study of dynamic tumor–immune interactions. Multi-omics integration offers a comprehensive overview of biomarker landscapes, while the rapid evolution artificial intelligence approaches enhances the analysis of complex, multidimensional datasets—ultimately enhancing predictive power and clinical utility. Despite substantial progress, challenges remain in standardization, data integration, and real-time monitoring. Nevertheless, incorporating spatial omics and single-cell omics into biomarker research holds transformative potential for personalized cancer immunotherapy. These emerging strategies pave the way for innovative diagnostic and therapeutic interventions, enabling precision oncology and elevating treatment outcomes for patients a wide range of tumor profiles.

This review aims to provide a comprehensive summary of the integration of spatial omics and single-cell omics in tumor immunotherapy biomarker discovery. Specifically, it focuses on how these emerging technologies address challenges related to tumor heterogeneity, immune evasion, and the dynamic TME. By elaborating on the principles, applications, and clinical potential of these technologies, the review will also critically evaluate their limitations, challenges, and the current gaps in their translational applications.

Dr. Ho Sang Jung and his research team from the Advanced Bio and Healthcare Materials Research Division at the Korea Institute of Materials Science(KIMS) have developed an optical biosensor capable of detecting trace amounts of cancer cell DNA in the bloodstream with high sensitivity, enabling early cancer diagnosis.