EurekAlert! Cancer Research - News Releases

News Releases

Updates every hour. Last Updated: 3-May-2025 19:09 ET (3-May-2025 23:09 GMT/UTC)

Tongue cancer organoids reveal secrets of chemotherapy resistance

Institute of Science Tokyo
Peer-Reviewed Publication

Tongue cancer (TC) cells can enter a chemo-resistant state by activating pathways related to autophagy and cholesterol synthesis, report researchers from Institute of Science Tokyo. Using a large-scale library of TC organoids they developed, the researchers performed comprehensive comparative analyses of chemo-sensitive and chemo-resistant cells. Their efforts shed light on promising avenues toward new treatments for tongue cancer.

Journal: Developmental Cell
Funder: Japan Society for the Promotion of Science, Takeda Science Foundation, Uehara Memorial Foundation, Medical Research Institute Basic Research Incentive Program, Project Mirai Cancer Research Grants, Nanken-Kyoten, TMDU

Study by Sylvester, collaborators highlights global trends in risk factors linked to lung cancer deaths

University of Miami Miller School of Medicine
Peer-Reviewed Publication

Lung and related cancer deaths decreased in the world’s 10 most populous countries over the past 40 years, but there is still a pressing need for public health measures to further reduce tobacco use and related mortality and the cancer risk from air pollution and asbestos exposure. The findings are published in eClinicalMedicine, part of The Lancet.

Journal: EClinicalMedicine

Research Spotlight: Lipid nanoparticle therapy developed to stop tumor growth and restore tumor suppression

Mass General Brigham
Peer-Reviewed Publication

Yang Zhang, PhD, and Jinjun Shi, PhD, both of the Center for Nanomedicine and Department of Anesthesiology, Perioperative and Pain Medicine at Brigham and Women’s Hospital, are co-senior authors of a paper published in ACS Nanoscience Au, “Lipid Nanoparticle Delivery of mRNA and siRNA for Concurrent Restoration of Tumor Suppressor and Inhibition of Tumorigenic Driver in Prostate Cancer.”

Journal: ACS Nanoscience Au
Funder: NIH/National Institutes of Health

MD Anderson Research Highlights for January 9, 2025

University of Texas M. D. Anderson Cancer Center
Peer-Reviewed Publication

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

Weight changes and heart failure risk after breast cancer development

JAMA Network
Peer-Reviewed Publication

About The Study: In this nationwide cohort study in the Republic of Korea, postdiagnosis weight gain was associated with an increased risk of heart failure after breast cancer development, with risk escalating alongside greater weight gain. The findings underscore the importance of effective weight intervention in the oncological care of patients with breast cancer, particularly within the first few years after diagnosis, to protect cardiovascular health.

Journal: JAMA Oncology

Research spotlight: Factors contributing to treatment resistance in CAR T therapies for solid tumors

Mass General Brigham
Peer-Reviewed Publication

Russell W. Jenkins, MD, PhD, a physician investigator in the Krantz Family Center for Cancer Research at the Mass General Cancer Center and an assistant professor of Medicine at Harvard Medical School, is senior author of a new study in Cancer Immunology Research, “TBK1 is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids”.

Journal: Cancer Immunology Research
Funder: Massachusetts Life Sciences Center Research Infrastructure Grant

New findings could lead to better treatment for blood cancer

Norwegian University of Science and Technology
Peer-Reviewed Publication

Chronic myelogenous leukemia is a form of cancer that can be treated with stem cell transplation,but many patients manage without it, as long as they receive effective medications called thyrokinase inhibitors. But there are five different medications for CML, and it is important to find the one that is most effective. A new method can help.

Journal: PNAS Nexus

What we eat affects our health — and can alter how our genes function

Stanford Medicine
Peer-Reviewed Publication

A new study from Stanford Medicine, which will be published in Nature Metabolism on Jan. 9, identified the direct epigenetic effects of two common byproducts of fiber digestion and found that some of the alterations in gene expression had anti-cancer actions.

Journal: Nature Metabolism

Lung cancer test predicts survival in early stages better than current methods

The Francis Crick Institute
Peer-Reviewed Publication

Researchers at the Francis Crick Institute, the UCL Cancer Institute and UCLH have shown that a test called ORACLE can predict lung cancer survival at the point of diagnosis better than currently used clinical risk factors. This could help doctors make more informed treatment decisions for people with stage 1 lung cancer, potentially reducing the risk of the cancer returning or spreading.

Journal: Nature Cancer

New insight: Scientists identify genes driving cancer spread

University of Southern Denmark Faculty of Health Sciences
Peer-Reviewed Publication

Cancer metastasis—the spread of cancer to other organs—is the leading cause of death among cancer patients. Researchers have now uncovered a “genetic signature” of 177 genes shared across multiple cancer types that drives this deadly process.

Journal: Molecular Cancer