Does genetics in infertile men impact on the pregnancy outcome through assisted reproductive technology?
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Updates every hour. Last Updated: 23-Oct-2026 03:16 ET (23-Oct-2026 07:16 GMT/UTC)
Male infertility affects about 7% of men, but its genetic causes are diverse and mostly unknown. We studied the genomes of 2054 infertile Chinese men to see how genetic factors impact fertility treatment outcomes. We found clear genetic causes in 11.4% of the men, including 13 genes never documented in human infertility before. While overall success rates for fertility treatments were similar across different groups, men with defects in 10 specific genes had very low pregnancy rates, and men with defects in 5 of those genes had no live births at all. We also discovered 41 candidate genes that may cause infertility. Ultimately, this study shows that genetic testing serves a powerful tool to potentially help, guide and improve fertility treatments.
PD-L1 is best known as the molecular "off switch" cancer cells use to disable the immune system at their surface. In recent years, however, it has become clear that PD-L1 can also enter the nucleus, yet what drives it there, and what it does once inside, has remained largely a mystery. Researchers from Zhejiang University and the University of Macau now provide an answer: DDB1, a protein adaptor, tags PD-L1 with K63-linked ubiquitin chains at the K185 site—a modification that does two things at once. It removes an acetylation mark that would otherwise keep PD-L1 out of the nucleus, and it enables the nuclear protein to bind DNA and switch on a program of immunosuppressive genes. In breast cancer patients resistant to immunotherapy, this nuclear form of PD-L1 was markedly elevated. Remarkably, thalidomide, an old drug already used for multiple myeloma, disrupts the DDB1–PD-L1 partnership. Combined with anti-PD-1 antibody in mouse models, the therapy shrank tumors dramatically, boosted infiltration of cancer-killing T cells, and extended survival. Published in Science Bulletin, the study uncovers a non-canonical route to immune evasion and offers a "repurposed" combination strategy poised for clinical testing.
Researchers from Zhejiang University and Northeast Forestry University have developed an exhalation-responsive optoelectronic clip that turns human breath into a clear optical ON/OFF signal. The wearable device combines optical microfibers with nanocellulose films and can be used for touch-free alerts, coded communication, and respiratory monitoring.
Topological corner states are protected against defects and structural imperfections that is beneficial for robust information or power transmission. In turn, vortex beams carrying orbital angular momentum can act as key carriers for information encoding. The integration of such states may enable robust topological photonic devices with large transmission capacity, yet fundamental barriers exist: zero-dimensional corner states reported so far in higher-order topological insulators with single-mode waveguides cannot readily accommodate vortices. In their article in Science Bulletin, a joint team of researchers from China and Russia has integrated them successfully and has shown that such states can exist in both linear and nonlinear regimes. According to the study, these corner vortex states exhibit outstanding robustness over a wide power range. Unlike vortex solitons in trivial lattices, they form without any power threshold, breaking the limitations of conventional vortex soliton generation. This work opens new avenues for topologically protected information transfer and wavefront control in topological photonics.
Researchers at Zhengzhou University have developed a Janus bioelectrode that protects weak body signals from electromagnetic interference. By combining a magnetic-dielectric aerogel with a liquid-metal conductive textile, the electrode records high-quality muscle and heart signals even in noisy electronic environments. When paired with machine learning, it enabled accurate recognition of human motions using fused EMG and ECG signals.
Shortly after transcription initiation, RNA polymerase II (Pol II) pauses near gene promoters before entering productive elongation, representing a key regulatory step in gene expression. In the recent study published in Science Bulletin, researchers from the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, combined acute protein degradation with genome-wide analyses to capture the immediate functions of the transcription factor GABPA in mouse embryonic stem cells. They discovered that, independently of its canonical partner GABPB, GABPA recruits the Integrator complex to promoter regions, thereby promoting productive transcription elongation. The study uncovers an unexpected role for a classical transcription factor and reveals how the Integrator complex is selectively recruited to specific genes.
A new study shows that plants communicate defensive warnings more effectively with species sharing similar volatile profiles, not necessarily close evolutionary relatives. Researchers exposed nine plant species to volatiles from invasive Phytolacca americana and found that defense priming was the dominant response. The strength of this response was better predicted by volatile similarity than by phylogenetic distance. The findings offer new insights into mechanisms of plant–plant communication.
Researchers developed a battery-free hydrogel bioelectronic patch that wirelessly monitors periodontal inflammation and releases miRNA therapy in response to disease-related enzyme activity. The device links local inflammation sensing with immune modulation, offering a new approach for integrated monitoring and treatment of periodontitis.