Actinobacteria TFDB is an integrated database for Actinobacteria transcription factors (TFs). The platform provides a one-stop resource for analyzing TF characteristics, target genes, ligands, and posttranslational modifications to advance microbiology and synthetic biology research.

Researchers have developed a programmable genome evolution platform called RAMPAGE that rapidly generates beneficial mutations in the industrial yeast Pichia pastoris. The technology enabled the evolution of strains that tolerate extremely high methanol concentrations, grow at elevated temperatures, and overcome growth defects caused by glycoengineering. The platform could accelerate the development of more robust microbial cell factories for sustainable biomanufacturing.

Researchers have engineered a multifunctional gallium-doped bioactive glass that selectively kills osteosarcoma cells and prevents bacterial infections while promoting bone regeneration. By localized delivery of gallium ions, this innovative biomaterial disrupts iron metabolism in cancer cells, triggering programmed cell death without harming healthy bone tissue. It simultaneously provides a robust defense against hospital-acquired pathogens like Pseudomonas aeruginosa.

A nanosensor measured nitric oxide from patient-derived stem cells. Autism patients produced ~6nM, intellectual disability patients ~11nM, and healthy individuals ~65nM, despite sharing the same genetic mutation. This differential production suggests nitric oxide levels can distinguish autism from other neurodevelopmental disorders with overlapping causes, offering a potential biomarker for more precise diagnosis.

Autophagy plays a cell-specific, bidirectional role in neuropathic pain-protective in some contexts but potentially detrimental in others. This review maps the complex regulatory network across neurons, astrocytes, and microglia, and critically evaluates therapeutic strategies targeting this cellular process, offering a roadmap for developing precision treatments.

Homeostatic Medicine, as an emerging integrative discipline, is driving a profound shift in medical paradigms from the traditional "eradication of pathogenic factors" to the "restoration of inherent homeostasis" by decoding the core mechanisms of the body's self-regulation. This discipline redefines the essence of health and disease, offering a novel theoretical framework and clinical intervention strategies for disease prevention and treatment.

Researchers from Chongqing Medical University discovered that excessive fibrin deposition drives chronic gum inflammation in diabetes by disrupting immune-epithelial crosstalk. By utilizing an engineered peptide (377P) to block fibrin-macrophage interactions, the team successfully suppressed inflammation, restored the mucosal barrier, and promoted alveolar bone healing in diabetic mice. This study identifies fibrin as a druggable target for diabetic periodontitis and potentially other systemic diabetic complications.

Sodium-ion batteries are gaining attention as a lower-cost and more resource-abundant alternative to lithium-ion systems, but their practical performance is often weakened before they truly begin working. A major obstacle is the loss of active sodium ions during the first charge-discharge cycle, especially when hard carbon anodes are used. A new study reports a residue-free electrolyte additive, sodium trifluoromethanesulfinate (NaSO₂CF₃), designed to release sodium ions at the right stage of battery formation while avoiding harmful solid leftovers. By combining molecular design, electrochemical testing, and pouch-cell validation, the work offers a practical route to improving initial efficiency, cycle life, and manufacturability in sodium-ion batteries.