Recently, a collaborative team from multiple institutions, including CIOMP, published a review article in Light: Science & Applications, systematically expounding on the cutting-edge developments in Surface-Enhanced Raman Scattering (SERS)-integrated optical waveguide technology. By reviewing two major technical pathways—remote sensing probes and microfluidic sensing platforms—the study thoroughly analyzes key innovations such as optical fiber structure design, SERS substrate modification, and the integration of emerging technologies. It clarifies the core advantages of this technology in improving detection sensitivity, simplifying operational procedures, and enabling miniaturization. The research not only summarizes the technological breakthroughs and application achievements in this field but also identifies future challenges such as large-scale fabrication and specificity optimization. It provides important academic references for the development of ultra-sensitive trace liquid detection technologies and is expected to drive innovations in detection technologies in fields such as biomedicine and environmental monitoring.

Ultraprecise fluorescence nanoscopy techniques such as MINFLUX and RASTMIN are enabling molecular-scale imaging and tracking in biologically relevant conditions. However, their implementation is challenging and requires stabilizing the position of the sample during the relatively long measurement times of minutes or tens of minutes. Scientists have developed an open-source system based on commonly available hardware that achieves sub-nanometric stabilization of the sample position for hours, opening the way for widespread application of single-molecule localization with true nanometer precision.