Biomaterial-based in vitro 3D modeling of glioblastoma multiforme

Highlights

• There is an urgent need to uncover major aberrant molecular pathways that could be targeted by new potential lead drug candidates in the treatment of glioblastoma multiforme (GBM).

• Lack of acceptable & reliable in vitro models which must guide the choice of in vivo GBM animal models hinders GBM therapy development.

• Development of 3D in vitro models could mimic the tumor microenvironment and the progression of the disease.

• Engineered biomaterials and technologies like 3D bioprinting could simulate GBM as closely as possible.

• 3D in vitro models will accelerate the preclinical testing and will aid in the development of an effective treatment for GBM