Neutrons Probe Structure of Enzyme Critical to Development of Next-Generation HIV Drugs (IMAGE)

DOE/Oak Ridge National Laboratory

Neutrons Probe Structure of Enzyme Critical to Development of Next-Generation HIV Drugs

Caption

This is a 3-D structure of the HIV-1 protease in cartoon representation with bound clinical drug darunavir (shown as sticks). The catalytic site contains two closely positioned aspartic acid residues. The insert depicts the hydrogen transfer reaction in the catalytic site, captured for the first time by neutron crystallography.

Credit

Jill Hemman and Andrey Kovalevsky, Oak Ridge National Laboratory

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Image credit: Jill Hemman and Andrey Kovalevsky, Oak Ridge National Laboratory

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