Fig 1 Mature Messenger RNA (IMAGE)

Institute for Basic Science

Fig 1 Mature Messenger RNA

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Mature messenger RNA (mRNA) has a long adenosine (A) tail, named poly(A) tail, for its regulation and protection. Over time, the tail is shortened by deadenylation enzymes, such as the CNOT complex (Pac-Man shape), resulting in mRNA degradation. This study found that mixed tails which contain non-A nucleotides, interfere with the A removal process. As a result, the mixed tail contributes to mRNA survival, so the body may keep making specific proteins.

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