Fidaxomicin Locks RNA Polymerase (IMAGE)

Rutgers University

Fidaxomicin Locks RNA Polymerase

Caption

Fidaxomicin (cyan) binds to RNA polymerase (gray) at the base of the clamp, a part of RNA polymerase that swings open by 17 degrees to allow RNA polymerase to bind to DNA and swings closed to allow RNA polymerase to hold onto DNA (open clamp in red at upper left; closed clamp in gray at upper left). Fidaxomicin locks the RNA polymerase clamp in the open position (red).

Credit

Wei Lin and Richard H. Ebright, Rutgers University

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