Three-Step DOTA-PRIT Based on Targeting with an IgG-scFv Bispecific Antibody (IMAGE)

Society of Nuclear Medicine and Molecular Imaging

Three-Step DOTA-PRIT Based on Targeting with an IgG-scFv Bispecific Antibody

Caption

Illustration of three-step DOTA-PRIT based on targeting with an IgG-scFv bispecific antibody (e.g., huA33-C825 for detection and treatment of colorectal cancer) with dual specificity for a tumor-associated antigen (e.g., GPA33) and M-DOTA haptens (e.g., Lu-177 DOTA).

Credit

Memorial Sloan Kettering Cancer Center

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