HIV-1 capsid protein (CA)-targeting PF74 suffers from prohibitively low metabolic stability (IMAGE)

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HIV-1 capsid protein (CA)-targeting PF74 suffers from prohibitively low metabolic stability

Caption

HIV-1 capsid protein (CA)-targeting PF74 suffers from prohibitively low metabolic stability. Structural modifications have yet to produce analogs with balanced potency and metabolic stability. Replacing the inter-domain interacting indole ring with less electron-rich isosteres allowed the identification of compound 20 with drastically improved metabolic stability while largely maintaining antiviral potency.

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Acta Pharmaceutica Sinica B

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