Humanized Mouse Model and Liraglutide (IMAGE)

Cell Press

Humanized Mouse Model and Liraglutide

Caption

This visual abstract depicts the work Abdulreda et al. Using a humanized mouse model, they show that, following the initial improvement in human pancreatic function, prolonged daily liraglutide treatment for over 200 days is associated with compromised insulin release and dysregulated glucose homeostasis, indicating islet cell metabolic exhaustion.

Credit

Abdulreda et al./<i>Cell Metabolism</i> 2016

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