Nuclear Transcripts (IMAGE)

Aarhus University

Nuclear Transcripts

Caption

Nuclear transcripts without poly(A)-tagged 3'ends ('pA-') are normally targeted to the RNA exosome via the cofactor NEXT (left), whereas transcripts with a poly(A) tail ('pA+') are targeted via PAXT (right). If NEXT-dependent decay fails, target RNAs acquire a poly(A)-tail and are handed to the exosome by PAXT. Such two-layered targeting ensures the robust decay of potentially hazardous RNAs.

Credit

Guifen Wu and Manfred Schmid, Aarhus University

Usage Restrictions

Image may be used only to illustrate the research described in the accompanying release.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.