Ryanodine Receptor (IMAGE)
Caption
High-resolution images of the ryanodine receptor, a protein associated with calcium-related disease, reveal in unprecedented detail the locations of more than 50 mutations that cluster in disease "hotspots" along the receptor. The images were made with beams of intense X-rays at the Stanford Synchrotron Radiation Lightsource, located at the Department of Energy’s SLAC National Accelerator Laboratory, and at the Canadian Light Source. The gray portion of the above image represents low-resolution information about the entire receptor. The high-resolution structure is shown in blue, where each sphere represents a single atom. Mutations identified in individual amino acids are colored red.
Credit
Image courtesy of Filip Van Petegem/University of British Columbia.
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