AAV immune-cloaking strategy (IMAGE)

Wyss Institute for Biologically Inspired Engineering at Harvard

AAV immune-cloaking strategy

Caption

AAVs with TLR9-inhibitory sequences incorporated into their genomes allowed significantly higher expression of a linked fluorescent reporter gene in the mouse retina (right) than AAVs that were lacking the sequences (left) following intravitreal administration.

Credit

David Copland/University of Bristol, UK

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